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KMID : 1004820100110010027
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Journal of Biomedical Research
2010 Volume.11 No. 1 p.27 ~ p.35
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Acute and Chronic Antiinflammatory Effects of Phellinus linteus Water Extract in Rats
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Lim Jeong-Hyeon
Kim Sung-Hwan
Park Na-Hyeong
Moon Chang-Jong
Kang Sung-Su
Kim Sung-Ho
Shin Dong-Ho
Kim Jong-Choon
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Abstract
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This study was conducted in order to evaluate the anti-inflammatory activities of Phellinus linteus (PL) water extract against carrageenan- and cotton pellet-induced acute and chronic inflammation in rats. Animals were divided into four experimental groups for conduct of acute and chronic inflammations studies: the vehicle control group, positive control group (aminopyrine 100 mg/kg), PL 10 mg/kg group, and PL 20 mg/kg group. Oral administration of PL water extract has dose-dependent anti-inflammatory effects against both acute and chronic inflammation models. In carrageenan-induced paw edema, significant inhibition was observed at 0.5 and 1 h in the PL 10 mg/kg group and at 0.5, 1, 2, 3, 4, and 6 h in the PL 20 mg/kg group. In cotton pellet-induced granuolma formation, PL water extract at 10 and 20 mg/kg/day also showed significant inhibition in dry weights of granuloma. Results of the free radical scavenging assay showed that PL has a dose-dependent scavenging activity against 2,2-diphenyl-1-picrylhydrazyl free radicals. The results obtained in this study indicate that this plant material may be used beneficially as an anti-inflammatory agent having antioxidant action.
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KEYWORD
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Phellinus linteus, Inflammation, Inhibitory effect, Antioxidant activity
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